Abstract
From the aerial parts of Clinopodium chinense var. parviflorum, nine new phenylpropanoids, clinopodic acids A-I (2-10), were isolated together with a known phenylpropanoid, rosmarinic acid (1). The structures of these new compounds were elucidated on the basis of spectroscopic analysis. Clinopodic acid C (4) showed MMP-2 inhibitory activity (IC(50) 3.26 microM).
MeSH terms
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Cinnamates / chemistry
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Cinnamates / isolation & purification
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Cinnamates / pharmacology
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Depsides / chemistry
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Depsides / isolation & purification
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Depsides / pharmacology
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Dioxanes / chemistry
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Dioxanes / isolation & purification*
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Dioxanes / pharmacology*
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Japan
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Lamiaceae / chemistry*
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Matrix Metalloproteinase Inhibitors*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Rosmarinic Acid
Substances
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Cinnamates
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Depsides
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Dioxanes
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Matrix Metalloproteinase Inhibitors
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clinopodic acid C